——If you like bird’s nest，you should to know more about Sialic acid.
Sialic acid, also known as bird’s nest acid, is the main bioactive component of bird’s nest, and it mainly exists in the form of N-acetylneuraminic acid in bird’s nest.
N-Acetylneuraminic acid (Neu5Ac or NANA) is the predominant sialic acid found in human cells, and many mammalian cells. Other forms, such as N-Glycolylneuraminic acid, may also occur in cells.
This residue is negatively charged at physiological pH and is found in complex glycans on mucins and glycoproteins found at the cell membrane. Neu5Ac residues are also found in glycolipids, known as gangliosides, a crucial component of neuronal membranes found in the brain.
Along with involvement in preventing infections (mucus associated with mucous membranes—mouth, nose, GI, respiratory tract), Neu5Ac acts as a receptor for influenza viruses, allowing attachment to mucous cells via hemagglutinin (an early step in acquiring influenzavirus infection).
Sialic Acids (a family of derivatives of neuraminic acid) are usually found as terminal structures of both N-linked and O-linked glycans.
Being located at the terminal position of glycans, sialic acids are a likely point of contact for many glycoprotein interactions. They are also important for the stability and 3D conformation of glycoproteins and are involved in many biological interactions:
Sialyation of IgG reduces ADCC and increases anti-inflammatory activity
Sialic acids increase the serum half-life of glycoproteins by preventing uptake by the liver’s asialoglycoprotein receptor
NGNA(Neu5Gc), a glycan not found in humans, can illicit an immune response and lead to increased neutralization of biopharmaceuticals.
Cell line choice can greatly influence the type of neuraminic acids present on a biopharmaceutical.
N-Acetylneuraminic acid/ Sialic Acid Usage
1.Widely used in biological systems.
2.It plays a very important biological function in cell differentiation, maturation, intercellular interaction and other physiological processes.
3.In the pharmaceutical industry, derivatives of sialic acid as precursors areincreasingly used in antiviral drugs, drugs for the treatment of neurological diseases and diagnostic reagents.
4.At present, there are two internationally recognized drugs for the treatment of H1N1 avian influenza, one is Tamiflu, the other is Leganqing (Zanamivir). And sialic acid is the main raw material of Leganqing.
Come on, king.
Whether you are purchasing Sialic Acid for personal use or business, please contact SRBio, we can provide you with products that satisfy you.