Parameter	Specification
Chemical Name	Nicotinamide Riboside Chloride
CAS Number	23111-00-4
Molecular Formula	C₁₁H₁₅N₂O₅Cl
Molecular Weight	290.70 g/mol
Specification	≥99.0% (HPLC)
Test Method	HPLC
Packaging	25kg/drum, double food-grade poly bags inside. Nitrogen-flushed foil packaging available.
Main Benefits	Elevates NAD+ levels, supports cellular energy metabolism, promotes DNA repair, enhances cognitive function
Application	Anti-aging supplements, cellular health formulas, sports nutrition, neuroprotective formulations

The Premier NAD+ Precursor: SRBio Nicotinamide Riboside (NR) Chloride

SRBio Nicotinamide Riboside (NR) is a high-purity, crystalline form of vitamin B3 that serves as a potent precursor to Nicotinamide Adenine Dinucleotide (NAD+), an essential coenzyme for cellular energy production, DNA repair, and metabolic regulation. As the body’s NAD+ levels naturally decline with age, supplementation with NR has emerged as a leading strategy to support healthy aging, mitochondrial function, and cognitive vitality. Our NR is produced through proprietary enzymatic synthesis, delivering ≥99.0% purity with exceptional stability and bioavailability.

Key Value Propositions:

✓ ≥99.0% HPLC-Verified Purity – Exceeds industry standards
✓ Proprietary Enzymatic Synthesis – Solvent-free, sustainable production
✓ Full Regulatory Support – GRAS, Novel Food dossiers available
✓ Custom Formulation Services – Tailored blends for rapid market entry

Uncompromising Quality: SRBio’s Manufacturing Excellence

1. Precision Purity Control

2. Advanced Enzymatic Synthesis Technology

• Proprietary Biocatalytic Process:

  • Enzymatic Conversion: Utilizes engineered enzymes for highly specific, solvent-free synthesis of Nicotinamide Riboside from nicotinamide and ribose precursors.

  • Green Chemistry: Water-based reaction system eliminates organic solvents, ensuring a clean, pure final product.

  • High Yield & Efficiency: Optimized reaction conditions achieve >95% conversion efficiency, reducing waste and production costs.

• Multi-Stage Purification:

  1. Microfiltration: Removes enzyme residues and high-molecular-weight byproducts.

  2. Ion-Exchange Chromatography: Selectively isolates NR chloride from ionic impurities.

  3. Controlled Crystallization: Produces uniform, high-purity crystals with optimal particle size distribution.

  4. Low-Temperature Drying: Fluidized-bed drying at ≤50°C preserves molecular integrity and prevents degradation.

• Annual Capacity: 20+ metric tons of high-purity NR chloride, with flexible production scheduling to match customer demand.

3. Stability & Shelf-Life Superiority

• Accelerated Stability Data: Retains ≥98% potency after 24 months at 25°C/60% RH (ICH Q1A tested).

• pH Stability: Stable in acidic to neutral environments (pH 3.0–7.0); formulated grades available for specific applications.

• Protection from Degradation: Nitrogen-flushed, moisture-proof foil packaging with desiccant prevents hydrolysis and oxidation during transit and storage.

• Storage Conditions: Store in cool, dry place, protected from light and moisture. Refrigeration recommended for long-term storage.

Scientific Evidence: Mechanism & Clinical Efficacy

1. NAD+ Elevation & Cellular Energy

• Mechanism of Action: Nicotinamide Riboside is a unique NAD+ precursor that enters cells via specific transporters and is converted to NAD+ through the salvage pathway. NAD+ is essential for:

  • Mitochondrial Function: Serves as a coenzyme for redox reactions in the electron transport chain, driving ATP production.

  • Sirtuin Activation: Activates sirtuins (SIRT1–7), longevity proteins that regulate cellular health, stress resistance, and metabolism.

  • PARP Activity: Required for poly(ADP-ribose) polymerase (PARP) enzymes that repair DNA damage.

• Clinical Outcomes:

  • ↑40–60% increase in whole-blood NAD+ levels after 4–8 weeks of NR supplementation (500–1000 mg/day) – Human clinical trials.

  • Enhanced mitochondrial oxidative capacity and cellular energy production.

2. Healthy Aging & Longevity Support

• Mechanism: NAD+ decline is a hallmark of aging. By replenishing NAD+ levels, NR supports multiple pathways implicated in the aging process:

  • Mitochondrial Biogenesis: Activates PGC-1α, promoting the generation of new, healthy mitochondria.

  • Autophagy: Supports cellular cleaning processes that remove damaged components.

  • Inflammation Modulation: Redox regulation and sirtuin activation help control chronic low-grade inflammation.

• Clinical Outcomes:

  • Improved muscle function and walking speed in older adults.

  • Reduced markers of inflammation (TNF-α, IL-6) in clinical studies.

  • Enhanced insulin sensitivity and metabolic health.

3. Cognitive & Neuroprotective Benefits

• Mechanism: Neurons have high energy demands and are vulnerable to NAD+ decline. NR supports:

  • Neuronal Energy Metabolism: Maintains ATP levels for synaptic transmission and plasticity.

  • DNA Repair in Neurons: Supports PARP activity to repair oxidative DNA damage.

  • Mitochondrial Health in Brain Cells: Protects against mitochondrial dysfunction implicated in neurodegenerative diseases.

• Clinical Outcomes:

  • Improved cognitive performance and memory in animal models.

  • Reduced markers of neurodegeneration in preclinical studies.

  • Ongoing human trials for Alzheimer’s disease and mild cognitive impairment.

4. Cardiovascular & Metabolic Health

• Mechanism: NR improves metabolic parameters through NAD+-dependent mechanisms:

  • Sirtuin-Mediated Effects: Enhances insulin sensitivity and glucose homeostasis.

  • Lipid Metabolism: Influences cholesterol and triglyceride levels.

  • Vascular Function: Supports endothelial nitric oxide synthase (eNOS) activity, improving blood flow.

• Clinical Outcomes:

  • Reduced blood pressure and arterial stiffness in clinical trials.

  • Improved lipid profiles (↓ LDL, ↑ HDL) in some studies.

  • Enhanced exercise performance and recovery.

5. Key Clinical Studies Summary

Formulation-Ready Advantages

Application-Specific Benefits:

• Anti-Aging & Longevity Supplements:

  • Capsules & Tablets: Excellent flow and compressibility for high-speed manufacturing. Available in micronized form for uniform blending.

  • Powder Blends: Free-flowing, disperses evenly in stick packs and sachets.

  • Combination Formulations: Ideal for stacking with Resveratrol, Pterostilbene, CoQ10, and other NAD+ boosters.

• Sports Nutrition:

  • Pre-Workout Formulas: Enhances energy metabolism and reduces fatigue.

  • Recovery Complexes: Supports mitochondrial repair and muscle recovery.

• Cognitive Health:

  • Neuroprotective Blends: Synergistic combinations with Phosphatidylserine, Bacopa Monnieri, and Ginkgo Biloba.

• Functional Foods & Beverages:

  • RTD Beverages: High solubility enables clear, stable formulations.

  • Functional Shots: Compatible with acidic beverage matrices (pH 3–4).

Supply Chain & Compliance Leadership

1. Audited Transparency & Traceability

• Full Traceability: Batch-specific Certificate of Analysis (COA) with complete impurity, heavy metal, and microbial data. Batch records and reference samples retained for every production lot.

• Supply Chain Visibility: Documented sourcing of all raw materials with supplier qualification audits.

• Dual Manufacturing Strategy: Production across certified facilities ensures business continuity and supply security.

2. Global Regulatory Certifications

3. Supply Chain Resilience

• Strategic Raw Material Partnerships: Long-term agreements with certified suppliers ensure production stability.

• Safety Stock: Strategic inventory maintained to accommodate urgent requirements.

• Flexible MOQs: Samples from 100g; commercial orders from 25kg; container loads for volume discounts.

• Global Logistics:

  • Sea Freight: 18-25 days to EU/US ports.

  • Air Freight: 3-7 days door-to-door.

  • Incoterms: FOB, CIF, DDP available.

• Audit Support: Full support for virtual and on-site audits; pre-organized audit packages available for qualified partners.

Competitive Breakdown: SRBio vs. Market Alternatives

Key Deficiencies in Standard NR:

• Variable Purity: Lower purity grades (95–98%) may contain impurities affecting safety and efficacy.

• Instability: Improper manufacturing or packaging leads to hydrolysis and potency loss.

• High Solvent Residues: Conventional synthesis may leave residual solvents >500 ppm.

• Limited Regulatory Support: Many suppliers lack comprehensive dossiers for global market entry (GRAS, Novel Food).

• Inconsistent Supply: Single-source manufacturing creates supply chain vulnerability.

SRBio’s Technology Edge:

Technical Partnership Program

1. Co-Development Services

• Custom Formulations:

  • Longevity Complex: NR + Resveratrol + Pterostilbene + CoQ10.

  • Cellular Energy Stack: NR + Creatine + D-Ribose + CoQ10.

  • Cognitive Vitality Blend: NR + Phosphatidylserine + Bacopa Monnieri + Ginkgo Biloba.

  • Metabolic Health Formula: NR + Berberine + Chromium + Cinnamon Extract.

• Custom Particle Engineering: Tailored particle size for direct compression, capsules, or suspensions.

• Stability Studies: ICH-guided protocols for your specific formulation matrix (tablets, capsules, powders, liquids).

• Reverse Engineering: Provide a sample of your current product; we’ll match or exceed its specification.

2. Market-Ready Solutions

• Private Label Kits: Turnkey formulas for capsules, tablets, powder blends, and functional beverages.

• Custom Packaging: Nitrogen-flushed foil bags, drums with desiccants, or branded packaging for direct-to-consumer launches.

• Regulatory Support: Full dossiers for GRAS, Novel Food, and FDA compliance to accelerate your market entry.

• Rapid Sampling: Receive 100g – 500g trial batches with full COA + MSDS within 72 hours.

Request Your Nicotinamide Riboside Discovery Kit

Includes:

• 100g High-Purity NR Chloride (≥99.0%, HPLC-verified)

• Full Certificate of Analysis (COA, TDS, MSDS)

• Stability Data Summary (24 months, ICH-compliant)

• Regulatory Dossier Excerpts (GRAS, Novel Food support)

• Formulation Guide for Anti-Aging & Cellular Health Applications

Partner with SRBio for Premium, Clinically Validated NR

Choose SRBio as your trusted Nicotinamide Riboside partner for:

• Uncompromising Purity – ≥99.0% HPLC-verified, solvent-free

• Scientific Validation – Backed by clinical studies on NAD+ elevation

• Regulatory Excellence – Full dossiers for global market access

• Technical Partnership – Supporting your product development from concept to launch

• Supply Chain Reliability – Dual manufacturing with 99.7% on-time delivery

• Proven Efficacy – The premier NAD+ precursor for healthy aging

Start Your Supplier Qualification:

→ Email: admin@plantextractssr.com
→ Phone: +86-13720408392
→ WhatsApp/WeChat: +86-13720408392

Video & Articles

Shipping & Packing Information

OEM SERVICE

We offer all-inclusive product development from consultation to delivery.
We make product proposals based on the customer’s requirements, from small to large lots.

Would You Like To Learn More?