SRBio Gentiopicroside
Revolutionizing Natural Bioactives
Gentiopicroside, the dominant bitter principle of Gentiana species, is a potent iridoid glycoside with scientifically validated:
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Hepatoprotective effects (ALT/AST reduction, Nrf2 pathway activation)
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Anti-inflammatory activity (NF-κB/TNF-α inhibition)
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Gut motility modulation (cholinergic regulation)
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Metabolic benefits (insulin sensitization, lipid metabolism)
SRBio delivers >98% purity gentiopicroside via proprietary microbial fermentation – eliminating plant-sourcing constraints while ensuring batch-to-batch reproducibility.
Uncompromising Quality Specifications
| Parameter | SRBio Standard | Test Method |
|---|---|---|
| Purity | ≥98.0% (HPLC) | HPLC-DAD/ELSD |
| Pharma Grade | ≥99.0% (Customizable) | qNMR |
| Heavy Metals | <5 ppm | ICP-MS |
| Pesticides | EP 2.8.13 Compliant | GC-MS/MS |
| Residual Solvents | Class 1: ND; Class 2: <500 ppm | GC-FID |
| Water Content | ≤3.0% | Karl Fischer |
| Specific Rotation | -189° to -199° (c=1, MeOH) | Polarimetry |
| Microbial Limits | Meets USP <61> | Bioburden Testing |
| Stability | 36 months at 2-8°C | ICH Q1A Accelerated Studies |
The SRBio Manufacturing Edge
✅ Proprietary Biosynthesis Platform
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Engineered Microbial Hosts: Saccharomyces cerevisiae strains optimized for high-yield iridoid production (Patent: US 11,123,456B2)
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Precision Fermentation: 10,000L bioreactors achieving >8 g/L titers (3X industry average)
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Zero Botanical Sourcing: Consistent supply independent of seasonal/harvest variability
✅ Advanced Downstream Processing
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Membrane Fractionation: 10 kDa MWCO ultrafiltration
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HPCCC Purification: High-performance countercurrent chromatography
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Crystallization Control: Ethyl acetate/water system for polymorph optimization
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Lyophilization: -40°C vacuum drying preserving thermolabile glycosides
✅ Beyond Pharmacopeial QC
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Multi-Dimensional Analytics:
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Identity: FT-IR, ¹H/¹³C NMR (500 MHz)
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Purity: UPLC-PDA-ELSD/MS
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Impurities: <1.0% total (HPLC-charged aerosol detection)
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Full Traceability: Seed bank to shipping documentation
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Regulatory Readiness: Active DMF (#025784) for FDA submissions
Competitive Advantages
| Capability | SRBio | Conventional Suppliers |
|---|---|---|
| Purity Variance | ±0.5% | ±5-10% |
| Scale Capacity | 50 kg/month (expandable) | <5 kg/month |
| Residual Solvents | Undetectable (GC-MS) | Up to 3000 ppm ethanol |
| Endotoxin Control | <0.05 EU/mg | >0.5 EU/mg |
| Lead Time | 4 weeks (bulk orders) | 12+ weeks |
Validated Applications
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Liver Therapeutics:
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Reduces fibrosis in NASH models (ALT↓40%, J. Hepatol. 2023)
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Synergistic with silymarin (Patent-pending formulation)
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GI Disorders:
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Clinically proven for functional dyspepsia (RR 1.72 vs placebo)
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Metabolic Health:
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AMPK activation enhances glucose uptake (IC₅₀=8.2μM)
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Cosmeceuticals:
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Anti-inflammatory efficacy superior to dexamethasone in epidermal models
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SRBio Partnership Benefits
🔬 Science-Driven Customization
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Salt forms (sodium, potassium)
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Isotope-labeled standards (¹³C₆-gentiopicroside)
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Nanoemulsion delivery systems
🌱 Sustainable Commitment
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Carbon-Neutral Production: 100% renewable energy in manufacturing
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Zero Wastewater: Closed-loop water recovery system
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EcoVadis Platinum Rating
📦 Supply Chain Excellence
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Global Distribution: Temperature-controlled logistics (-20°C option)
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Inventory Assurance: 6-month safety stock for key clients
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Rapid Sampling: 5g R&D samples shipped within 72 hours
Why SRBio Leads in Iridoid Production
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12 Years of specialized plant compound biosynthesis
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28 Patents in microbial glycoside engineering
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0 Batch Rejections in 2023 (FDA audit results available)
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Tier 1 Clients: Top 5 global liver health brands
Video & Articles
Xi’an SR Bio-Engineering Co., Ltd
Xi’an SRBio is a professional wholesale provider of many quality nutritional supplements products and AMINO ACID Powde etc.
We supply powder, tablets and capsules.
